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Open Access Open Badges Research article

Evaluation of vegetable and fish oils diets for the amelioration of diabetes side effects

Nadia Saleh Al-Amoudi1* and Huda A Abu Araki2

Author Affiliations

1 Nutrition and Food Department, King Abdulaziz University, P. O. Box 3108, Jeddah 23435, Saudi Arabia

2 Laboratory Animals Unit, King Fahad Medical Research Center, P. O. Box 80216, Jeddah 21589, Saudi Arabia

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Journal of Diabetes & Metabolic Disorders 2013, 12:13  doi:10.1186/2251-6581-12-13

Published: 21 February 2013



In the existing literature, the evidence regarding the effects of certain oils on the amelioration of hyperglycemia contains ambiguities and contradictions; and with regard to other oils, the quantity of existing studies is scant.


To assess the influence of sesame, garden rocket, organic olive, thyme, fenugreek, hazelnut, and cod liver oil on serum glucose, liver function, and kidney functions.


Male albino rats were injected with streptozotocin (60 mg/kg BW). The duration of the experiment was 28 days. Maximum recovery of occurred wasting attributable to diabetes was found in the sesame and cod liver groups.


With respect to ameliorating and/or preventing the side effects of diabetes on liver function, this experiment showed that thyme, organic olive, cod liver, and fenugreek oils were efficacious. Turning to serum lipid profile, organic olive oil not only ameliorated but also prevented the changes of TC, HDL, LDL, and AI. Vegetable and cod liver oil diets resulted in a marked amelioration of renal dysfunction, but they were unable to prevent this side effect. Similar, oil diets were unable to mask the increase in serum glucose due to diabetes mellitus.


On the basis of these findings, it could be recommended that when attempting oil diet treatment for the side effects of diabetes, a blend of the various specific treatments which showed best results should be employed in order to achieve improvement with respect to all parameters; and in part, this is because a synergism between the various treatments can be expected.

Vegetable oils; Fish oils; Diets; Diabetes cod liver oil; Sesame oil; Lipid profile; Liver function; Kidney function