Open Access Research article

Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?

Mostafa Qorbani12, Hamid Reza Bazrafshan3, Mehrdad Aghaei3, Hossien Shadpour Dashti3, Aziz Rezapour4, Hamid Asayesh5, Rasool Mohammadi6, Younes Mohammadi7, Hossein Ansari8 and Morteza Mansourian9*

Author Affiliations

1 Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran

2 Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

3 Bone joints & Connective Tissue Research Center, Golestan University of Medical Sciences, Gorgan, Iran

4 Hospital Management Research Center, Iran University of Medical Sciences, Tehran, Iran

5 Department of Medical Emergency, Qom University of Medical Sciences, Qom, Iran

6 Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

7 Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

8 Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

9 Department of Health Education, Ilam University of Medical Sciences, Ilam, Iran

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Journal of Diabetes & Metabolic Disorders 2013, 12:38  doi:10.1186/2251-6581-12-38

Published: 8 July 2013

Abstract

Background

Osteoporosis is the most common metabolic bone disease with complicated, multifactorial and heterogenic nature that has no known pathological cause. As the role of Diabetes Mellitus (DM) and thyroid dysfunctions in the prevalence of osteoporosis is not exactly known, therefore this study was designed to evaluate the probable association between osteoporosis with DM and thyroid dysfunctions in Iranian patients.

Methods

In this cross-sectional study, 300 subjects out of the total number of patients referring to Gorgan bone densitometry centers (3000subjects) were selected via random sampling method in 2009. Individual characteristics, DM, thyroid dysfunctions and densitometry results were collected from densitometry records. Data analysis was carried out by SPSS version 16 software and by using Chi square and T-test. The level of significance in all tests was considered 0.05.

Results

The mean of T-score in lumbar and femoral areas of diabetic patients were -0.87 ± 1.08 and -1.94 ± 1.33 and in patient with thyroid dysfunctions was -0.80 ± 1.09 and -1.64 ± 1.24 respectively. The mean of BMD in lumbar and femoral areas of diabetic patients were 0.96 ± 0.19 and 0.75 ± 0.19 and in patient with thyroid dysfunctions were 0.96 ± 0.17 and 0.76 ±0.19 respectively. The mean of BMI in osteoporotic subjects in the lumbar and femoral areas were 25.94 ± 5.62 and 26.95 ± 5.20 respectively. The association between BMI and BMD in the lumbar and femoral areas were statistically significant, but the association between DM and thyroid dysfunctions with BMD and T-score in the femoral and lumbar areas was not statistically significant (P-value > 0.05).

Conclusion

The results of current study show that there is no association between DM and thyroid dysfunctions with osteoporosis.

Keywords:
Osteoporosis; Bone density; Diabetes mellitus; Thyroid diseases