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Open Access Highly Accessed Research article

Predictive factors of diabetic complications: a possible link between family history of diabetes and diabetic retinopathy

Zhila Maghbooli1, Parvin Pasalar2, Abbasali Keshtkar1, Farshad Farzadfar3 and Bagher Larijani1*

Author Affiliations

1 Endocrinology and Metabolism Clinical Sciences Institute of Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran

2 Biochem, Department Faculty of Medicine Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran

3 Endocrinology and Metabolism Population Sciences Institute of Tehran University of medical sciences, 4th floor, No. 4, Ostad Nejatollahi St, Enqelab Ave, 1599666615 Tehran, Iran

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Journal of Diabetes & Metabolic Disorders 2014, 13:55  doi:10.1186/2251-6581-13-55

Published: 8 May 2014

Abstract

Background

The aim of this study was assessment of predictive factors of diabetic retinopathy.

Methods

A cross-sectional study was designed by recruiting 1228 type 2 diabetic patients from a diabetes referral clinic over a six-month period (from July to December, 2012). Diabetes risk factors, complications, laboratory results have been recorded.

Results

Of the 1228 diabetic patients (54% women, mean age 58.48 ± 9.94 years), prevalence of diabetes retinopathy was 26.6%. There were significant associations between retinopathy and family history of diabetes (p = 0.04), hypertension (p = 0.0001), diabetic duration (p = 0.0001), poor glycemic control (p = 0.0001) and age of onset of diabetes (p = 0.0001). However, no significant associations were found between retinopathy with dyslipidemia and obesity. In logistic regression model, poor glycemic control (p = 0.014), hypertension (p = 0.0001), duration of diabetes (p = 0.0001) and family history of diabetes (p = 0.012) independently predicted retinopathy after adjustment for age and sex.

Conclusions

Diabetic complications are resulting from an interaction from genes and environmental factors. A family history of diabetes is pointing toward a possible genetic and epigenetic basis for diabetic retinopathy. Our findings suggest the role of epigenetic modifications and metabolic memory in diabetic retinopathy in subjects with family history of diabetes.

Keywords:
Diabetic retinopathy; Epigenetic; Family history of diabetes